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Uludağ Üniversitesi Tıp Fakültesi Dergisi
Article . 2022 . Peer-reviewed
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Kurkuminin Ishikawa Hücre Hattında Canlılık ve Apoptoz Üzerindeki Etkileri

Authors: Hatice Kübra BAŞALOĞLU; Çiğdem YENİSEY; Mehmet TURGUT; Emel Öykü ÇETİN UYANIKGİL; Yiğit UYANIKGİL;

Kurkuminin Ishikawa Hücre Hattında Canlılık ve Apoptoz Üzerindeki Etkileri

Abstract

Kurkumin (diferuloilmetan), başta Çin olmak üzere Asya ülkelerinde kanser tedavisi için alternatif tıpta kullanılmaktadır. Son yıllarda, kurkuminin bazı kanser tiplerine karşı doğal bir antitümöral ajan olduğu öne sürülmektedir. Bu araştırmanın amacı, Ishikawa endometriyal kanser hücre hattı üzerinde kurkuminin antitümöral etkilerini değerlendirmektir. Ishikawa hücreleri 10, 20, 40, 80 ve 100 μM konsantrasyonlarda kurkumin ile inkübe edildi. 24, 48 ve 72 saatlik inkübasyon sonrası apoptoz, kaspaz 3/7 değerleri ve hücre canlılığı değerlendirildi. Kurkuminin in vitro olarak, Ishikawa hücre canlılığını üzerinde inhibe edici etki gösterdiği saptandı. Ayrıca 48 saat kurkumin ile 10 ve 20 μM konsantrasyonlarda apoptoz en yüksek düzeyde iken, 100μM konsantrasyonlarda hücrelerin apoptoz yerine nekroza gittiği gözlendi. Öte yandan kaspaz 3/7 enzim sonuçları, 80 μM kurkumin konsantrasyonunda en yüksek düzeyde saptandı. Kurkumin, Ishikawa hücre hattı üzerinde farklı hücre ölüm yolağını etkilemektedir.

Country
Turkey
Keywords

Apoptoz, Ishikawa hücre hattı, kurkumin Apoptosis

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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