Molecular Modelling Study of the 3D Structure of the Bovine Viral Diarrhea Virus (BVDV) Helicase
Copyright policy )Molecular Modelling Study of the 3D Structure of the Bovine Viral Diarrhea Virus (BVDV) Helicase
Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family of viruses and constitutes a very important pathogen for livestock around the world [1]. The viral helicase is an enzyme essential for the proliferation and transmission of the virus. In this work a 3D-model of the BVDV helicase was produced using homology modelling techniques and the known 3D-structure of the hepatitis C helicase of the Flaviviridae family as template, in an attempt to provide the means for structure-based design of novel anti-BVDV agents.
- Cardiff University United Kingdom
- Harokopio University Greece
Models, Molecular, Diarrhea Viruses, Bovine Viral, Molecular Sequence Data, Static Electricity, Hepacivirus, Protein Structure, Tertiary, Substrate Specificity, Adenosine Triphosphate, Imaging, Three-Dimensional, Structural Homology, Protein, RNA, Viral, Computer Simulation, Amino Acid Sequence, Sequence Alignment, Conserved Sequence, RNA Helicases
Models, Molecular, Diarrhea Viruses, Bovine Viral, Molecular Sequence Data, Static Electricity, Hepacivirus, Protein Structure, Tertiary, Substrate Specificity, Adenosine Triphosphate, Imaging, Three-Dimensional, Structural Homology, Protein, RNA, Viral, Computer Simulation, Amino Acid Sequence, Sequence Alignment, Conserved Sequence, RNA Helicases
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