This research probes into the strain changes of the great saphenous vein (GSV) during step exercises. Microelectromechanical Systems (MEMS) were used to process and develop Gauge Factors (GF=4.79±0.247), 5 males and 5 females with an average age of 20±0.6 years were asked to engage in step exercises (with step height of 25cm), and the strain changes of the GSV in the lower limbs of the dorsal venous arch were measured. The results show that the effect the exercise has on the vein vessel is not prominent within 0.87 min; between 0.87 and 13.71 min, the average rates of the strain changes in the GSV show a linear increase; after 13.4±0.31 min, the linear curve of the increase rate is alleviated. This shows that to prevent varicose veins in the lower limbs, continuous exercise between 0.87 to 13.71 minutes has better effects in training. Exercising for over 13.71 minutes has its beneficial effects, but the effects are considerably less obvious than exercising for 0.87∼13.71 min.