To improve the management of collaborative manufacturing tasks in MES and promote the digital transformation of discrete manufacturing enterprises, the collaborative manufacturing of discrete manufacturing based on MES has been studied. First, the business flow of collaborative manufacturing in an MES was analyzed systematically. Second, the algorithm of detailed scheduling for collaborative tasks was studied, and a model of external collaborative resources was designed. Then, a solution of collaborative scheduling was presented based on a hybrid genetic algorithm. Finally, a solution for the execution process management of collaborative manufacturing was promoted based on the integration of MES and ERP. The technologies researched can improve the general management of collaborative manufacturing and guide practical production management.