The damage of rock slopes is often very sudden, and a series of reinforced concrete anti-slide piles are set on the slope, which can effectively control the landslide and ensure the safety of people’s lives. In this paper, through numerical simulation and theoretical analysis, the parameter sensitivity analysis of anti-sliding piles with different cross-sectional shapes and different pile spacings, the displacement and stress laws of anti-sliding piles under different parameter changes are obtained. At the same time, through theoretical analysis of the anti-sliding mechanism of anti-sliding piles under different parameters, it provides some theoretical guidance for the parameter selection of anti-sliding piles in actual engineering construction. The result shows: the distribution law of stress and displacement under different parameters is analyzed, and it is found that the anti-sliding ability of circular anti-sliding piles is weaker when the pile spacing is larger. When the pile spacing of the rectangular anti-sliding pile is large, the load it can bear is large. When the pile spacing is too wide, the soil arch effect gradually weakens, and the effect of anti-slide piles is weakened.