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Novel Rapid Test for Detecting Carbapenemase

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Apr 2020Publisher:Centers for Disease Control and Prevention (CDC)Journal:Emerging Infectious Diseases, volume 26, pages 793-795 (issn: 1080-6040, eissn: 1080-6059,

Authors: Michael Pigula; Akilan Palanisami; Shoaib Ashraf; Tayyaba Hasan; Jerrin Kuriakose; Yanfang Feng;

doi: 10.3201/eid2604.181655

pmid: 32186503

pmc: PMC7101118

Novel Rapid Test for Detecting Carbapenemase

- Summary
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Abstract

We developed a carbapenemase test based on the ability of imipenem to inhibit noncarbapenemase β-lactamases. The test uses bacterial isolates with a fluorescent β-lactamase substrate, producing objective results with 100% sensitivity and specificity in 10 minutes. The assay is inexpensive and consists of only 1 mixing step.

Related Organizations

Harvard University
United States
Harvard-MIT Health Sciences & Technology
MASSACHUSETTS GENERAL HOSPITAL

Keywords

R, Infectious and parasitic diseases, RC109-216, Microbial Sensitivity Tests, gram-negative bacteria, Sensitivity and Specificity, beta-Lactamases, Anti-Bacterial Agents, carbapenemase, Imipenem, rapid test, Bacterial Proteins, Laboratory diagnosis, Research Letter, Medicine, fluorescence, bacteria

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	10
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%