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Sensitivity of Mycobacterium leprae to Telacebec

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Mar 2022 Singapore Publisher:Centers for Disease Control and Prevention (CDC)Journal:Emerging Infectious Diseases, volume 28, pages 749-751 (issn: 1080-6040, eissn: 1080-6059, Copyright policy )Funded by:NIH | Zeiss LSM 510 Laser Scann..., EC | LEPVORS
Authors: Lahiri, Ramanuj; Adams, Linda B.; Thomas, Sangeeta Susan; Pethe, Kevin;

doi: 10.3201/2803.210394 , 10.3201/eid2803.210394

pmid: 35202539

pmc: PMC8888226

Sensitivity of Mycobacterium leprae to Telacebec

Abstract

The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials.

Country
Singapore
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Keywords

Pyridines, Telacebec, R, Imidazoles, Infectious and parasitic diseases, RC109-216, tuberculosis and other mycobacteria, Mycobacterium leprae, Piperidines, Leprosy, Research Letter, Medicine, :Medicine [Science], telacebec, Hansen disease, bacteria, leprosy

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 15
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
15
Top 10%
Average
Top 10%
Green
gold
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