In the Medical Bulletin, 1897, one of us (Ott) stated, the spleen of all the animal extracts has the most marked effect on peristalsis. It produces the largest peristaltic waves. When the spleen was removed then peristalsis decreased. If now spleen extract was injected, then peristalsis was restored to a considerable extent above normal.In 1908, Zuelzer (Dohrn, Marxer and Zuelzer, “Specifische Aufregung der darm Peristaltik, etc.,” Berliner Klinische Wochenschrift, 1908, No. 48) with others confirmed the preceding results. He prepared an extract of the spleen, called “hormonal,” for intravenous and intramuscular injection in man for the cure of chronic constipation. He reports marked success in this condition. This statement has been confirmed by Saar, Henle, Unger and several others.