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The Stability and the Stabilization of Testicular Hyaluronidase

Name: The Stability and the Stabilization of Testicular Hyaluronidase
Keywords: Hyaluronoglucosaminidase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1949Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 71, pages 295-298 (issn: 1535-3702, eissn: 1535-3699,

Authors: James W. Cassidy; Sibylle Tolksdorf; D. Roy McCullagh; Florence Valentine;

doi: 10.3181/00379727-71-17169

pmid: 18134042

The Stability and the Stabilization of Testicular Hyaluronidase

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Abstract

Summary1. Testicular hyaluronidase in bulk assaying 150 TRU per mg is stable at room temperature for more than one year.2. Hyaluronidase in concentrated aqueous solution is stable for several months at 10°.C Dilute solutions of the enzyme are less stable.3. Hyaluronidase dried from the frozen state in vials can be stabilized by the addition of polypeptide. Its half-life at 60°C is thereby extended 10 to 20 times.4. Certain bacteriostatic agents can be used throughout the production of hyaluronidase without decreasing the activity of the enzyme.

Related Organizations

Schering-Plough
United States

Keywords

Hyaluronoglucosaminidase

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