In a series of observations on the neurocytes of the cortex, the cerebellum and the medulla in shock, infection, Graves'disease, iodoform, strychnia and alcohol poisoning, these cells, principally in the fatal cases, showed a marked alteration in the nucleusplasma relation and in the size of the cell.In the infections, in Graves'disease, in iodoform poisoning and in shock, these changes while varying greatly were in some degree seen in most of the cells. In alcohol and strychnia poisoning some cells were extremely altered while others were but slightly or not at all changed. The changes were studied by counting and measurement and compared with the normal. Due allowance was made for the great variation in the normal. A study of a large series of normal animals served as a basis for comparison. For example, in the normal no cell showing destruction of the nucleus and nucleolus with rupture of the cell membrane was observed, while in the fatal cases from the various diseases studied, there were many such ce...