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Comparison of Leukocytic Pyrogen and Leukocytic Endogenous Mediator

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1977Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 154, pages 224-227 (issn: 1535-3702, eissn: 1535-3699,

Authors: Ralph F. Kampschmidt; Larry A. Pulliam; Charles R. Merriman;

doi: 10.3181/00379727-154-39642

pmid: 840859

Comparison of Leukocytic Pyrogen and Leukocytic Endogenous Mediator

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Abstract

SummaryLeukocytic pyrogen was subjected to a five-step purification scheme, and quantitative assays for both leukocytic pyrogen and leukocytic endogenous mediator (LEM) were made. At each step of the purification scheme, the active fractions, in addition to producing fever, lowered plasma iron and zinc concentrations, elevated fi-brinogen concentrations, and caused a release of neutrophils from bone marrow. It appears, therefore, that LEM and leukocytic pyrogen are the same molecule.

Related Organizations

Samuel Roberts Noble Foundation
United States

Keywords

Leukocyte Count, Zinc, Neutrophils, Pyrogens, Iron, Leukocytes, Animals, Fibrinogen, Rats

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	121
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%