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The Alteration of Blood Group Antigens by Carbodiimide

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1972Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 139, pages 1,144-1,147 (issn: 1535-3702, eissn: 1535-3699,

Authors: Kay J. Nielsen; Jack D. Wahlen; Crichton McNeil; Ernest Sax;

doi: 10.3181/00379727-139-36316

pmid: 4623412

The Alteration of Blood Group Antigens by Carbodiimide

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Abstract

SummaryEthyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (CDD) inhibits the expression of many blood group antigens of the human red cell. A notable exception is the ABO system. The alteration did not seem to be reversible by ordinary methods. Sialic acid blocks the effect of CDD and may indicate the structure of the terminal chemical configuration.

Keywords

Erythrocytes, Rh-Hr Blood-Group System, Propylamines, Temperature, Urea, Neuraminic Acids, Imines, ABO Blood-Group System

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