SummaryFifteen normal male and 15 normal female subjects living permanently at a mining town located at an altitude of 14,000 ft in the central Andean plateau demonstrated elevations of the values of serum urate, creatinine, and hematocrit when compared with equal numbers of normal subjects living at sea level. Of the HA male group, three subjects (20%) have urate values above 8 mg/100 ml, the level at which urate deposition in tissues might take place. There is a high degree of correlation between the serum urate levels and the hematocrit and between the serum creatinine and the hematocrit in the series as a whole. Although the mean hematocrit values of the HA females and the SL males are comparable, the latter have higher urate levels, reflecting the influence of sex on urate levels.