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Experimental Biology and Medicine
Article . 1966 . Peer-reviewed
Data sources: Crossref
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Experimental Biology and Medicine
Article
Data sources: Microsoft Academic Graph
Proceedings of The Society for Experimental Biology and Medicine
Article . 1967
Data sources: Europe PubMed Central
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Counteraction of Narcotic Antagonist Analgesics by the Narcotic Antagonist Naloxone

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1966 English Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 123, pages 755-758 (issn: 1535-3702, eissn: 1535-3699, Copyright policy )
Authors: Harold Blumberg; Hyman B. Dayton; Peter S. Wolf;

doi: 10.3181/00379727-123-31595

pmid: 4381176

Counteraction of Narcotic Antagonist Analgesics by the Narcotic Antagonist Naloxone

Abstract

SummaryWhen the potent narcotic antagonist, naloxone, was injected subcutane-ously into mice and rats simultaneously with narcotic antagonist analgesics, naloxone counteracted the writhing test analgesic activity of the antagonists. Naloxone completely antagonized the potent analgesic activity of pentazocine, nalorphine, cyclazocine, and cy-clorphan, and also antagonized the weak analgesic activity of levallorphan.

Keywords

Analgesics, Mice, Pentazocine, Levallorphan, Morphinans, Nalorphine, Narcotic Antagonists, Animals, Cyclazocine, Drug Antagonism, Rats

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 95
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
95
Top 10%
Top 1%
Top 10%
gold
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