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Dose-Response Relationship in Aminonucleoside Nephrosis.

Name: Dose-Response Relationship in Aminonucleoside Nephrosis.
Keywords: Nephrosis, Nucleosides, Puromycin Aminonucleoside

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1963Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 112, pages 506-510 (issn: 1535-3702, eissn: 1535-3699,

Authors: Vincent R. Hunt; Carl S. Alexander; Herbert T. Nagasawa;

doi: 10.3181/00379727-112-28089

pmid: 14011942

Dose-Response Relationship in Aminonucleoside Nephrosis.

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Abstract

SummaryAdministration of 1–3 mg of PA subcutaneously to normal rats at intervals of 1–2 weeks produced significant proteinuria after a prolonged latent period provided the total dose exceeded a threshold dose of approximately 4–5 mg. Analysis of the cumulative dose-response curves revealed that doses administered subcutaneously at biweekly intervals were more effective in producing proteinuria than the same total dose given on a daily or weekly schedule. While the mechanism of PA nephrotoxicity is still not known, it is unlikely that it acts by direct enzyme inhibition.

Related Organizations

University of Minnesota Morris
United States

Keywords

Nephrosis, Nucleosides, Puromycin Aminonucleoside

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