Cholinergic Stimulation of Globus Pallidus in Man.

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1959 English Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 101, pages 68-69 (issn: 1535-3702, eissn: 1535-3699,

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Authors: B S, NASHOLD;

doi: 10.3181/00379727-101-24835

pmid: 13658194

Cholinergic Stimulation of Globus Pallidus in Man.

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Abstract

SummaryA 10% solution of acetylcholine chloride injected into the globus pallidus of persons with Parkinsonism resulted in initial excitatory stage with increase in tremor and parasympathetic activation. Parasympathetic response was blocked by intracerebral injection of an anticholinergic drug, oxyphenonium bromide. The exact mechanism of drug action is not known, although cholinergic sensitive regions appear to exist in or near the globus pallidus.

Related Organizations

Duke University
United States

Keywords

Male, Parasympathomimetics, Cholinergic Agents, Humans, Globus Pallidus, Acetylcholine, Basal Ganglia

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