Malaria, a pest-carried infectious affliction, led to Plasmodium deadbeats, remnants of a significant worldwide well-being burden, specifically in tropical and subtropical domains. Understanding the plant structure of disease transmission is critical for cultivating productive control procedures. This review aims to provide an inclusive survey of the organic aspects that are complicated in the broadcast of disease. The biological clock of Plasmodium parasites includes complex interplays between the mosquito heading and the human host. Anopheles mosquitoes symbolize headings for malaria broadcast, accompanying various varieties capable of communicating various Plasmodium classes. The transmission phase starts when a polluted female pest takes blood food, presenting sporozoites into the human bloodstream. Sporozoites travel to the liver, where they contaminate hepatocytes and bear copies, leading to the release of merozoites into the bloodstream. Merozoites ravage rose ancestry containers, initiating the indicative step of the affliction and facilitating further broadcast to mosquitoes all the while after ancestry meals. In the past, intercourse duplication occurred, bearing sporozoites that moved to the salivary glands, ready to contaminate another human host upon the mosquito's next bite. Various determinants influence sickness broadcast action, including heading class, incidental conditions, human action, and the dependent transmission of traits from parents to offspring. Climate change, land use changes, and insecticide fighting pose supplementary challenges to sickness control exertions. Advancements in molecular plant structure, genomics, and heading plant structure have deepened our understanding of malaria broadcast systems and promoted the occurrence of innovative control invasions. Strategies in the way that poison-treated bed nets, household leftover spraying, and antimalarial drugs have provided significant reductions in sickness occurrence and death. However, continuous research is necessary to address emerging challenges and expand tenable malaria control measures. Integrated approaches, containing heading control, drug growth, and society engagement, are essential for obtaining sickness removal goals and lowering the worldwide burden concerning this devastating affliction.