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Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
Article . 1999 . Peer-reviewed
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Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
Article . 1999
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https://dx.doi.org/10.3143/ger...
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Mechanism of Insulin Resistance.

インスリン抵抗性
descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1999 Japanese Publisher:The Japan Geriatrics SocietyJournal:Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, volume 36, pages 389-395 (issn: 0300-9173, Copyright policy )
Authors: T, Kadowaki;

doi: 10.3143/geriatrics.36.389

pmid: 10513209

Mechanism of Insulin Resistance.

Abstract

インスリン抵抗性の成因は遺伝素因, 肥満などの生活習慣, 高血糖それ自体に大別される. 肥満に伴うインスリン抵抗性は肥大した脂肪細胞から分泌されるTNF-αや遊離脂肪酸 (FFA) が関与している. インスリン抵抗性の分子レベルでの共通の特徴は, (1)インスリン受容体チロシンキナーゼ・P13キナーゼ活性の低下, (2)GLUT4トランスロケーションと糖取り込み低下, (3)グリコーゲン合成酵素活性低下である. インスリン抵抗性は, 膵β細胞のインスリン分泌能や増殖能に障害のある場合には, 2型糖尿病の強力な発症要因となる. 最近, 糖代謝に関するインスリン作用に加えて, 血管や腎でのインスリン作用が解明されつつある. IRS-1欠損マウスはインスリン抵抗性のモデル動物である, シンドロームXの諸徴候を呈する. 今後, インスリン抵抗性の分子機構の解明により, 2型糖尿病やシンドロームXをはじめとするインスリン抵抗性症候群のより良い治療・予防を目指すことが重要である.

Keywords

Animals, Humans, Insulin Resistance, Diabetes Mellitus, Experimental, Microvascular Angina

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
gold