Millions of tons of fiberglass are produced annually for a variety of applications. Because of stringent quality requirements and operational characteristics of the manufacturing plants, a significant quantity of fiberglass that does not meet required specifications of the industry ends up as waste in landfills. This study investigated the use of ground glass fiber (GGF) that had been discarded by plants because it did not meet prescribed standards, as a supplementary cementitious material (SCM) for portland cement. Three replacement levels (10%, 20%, and 30% by mass) for portland cement in paste, mortar, and concrete mixtures were studied. Mechanical and durability properties of the mixtures were compared with two control mixtures: a mixture made up of 100% portland cement and a mixture with 25% Class F fly ash as a cement replacement material. It was observed in these studies that even though replacement of portland cement with GGF did not lead to any significant changes in the mechanical behavior of hardened concrete, there were significant improvements in durability properties at replacement levels up to as high as 20%. The use of GGF was found to improve significantly the resistance of mortar mixtures to alkali–silica reaction and sulfate attack. In addition, the use of GGF as an SCM significantly reduced the chloride ion permeability of concrete. Results of this study show that using GGF as an SCM can result in a better durability performance compared with a mixture with a similar level of Class F fly ash.