Abstract This chapter addresses the question of how to deal with multiaxial stresses and strains when using the strain-range partitioning method to analyze the effects of creep fatigue. It is divided into three sections: a general discussion on the rationale used in formulating rules for treating multiaxiality, a concise listing of the rules, and an example problem in which axial creep-fatigue data is used to predict the torsional creep-fatigue life of type 304 and 316 stainless steel. The chapter also includes a brief introduction in which the authors outline the challenges presented by multiaxial loading and set practical limits on the problem they intend to treat.