This chapter of the SME Surface Mining Handbook deals with long-distance slurry pipelines, defined asthose longer than 10 km is used to transport solid materials, including ore, concentrate, and tailings,mixed with water, where the latter acts as a medium. Such pipelines tend to pass through public andprivate sites, and commonly through natural topographies and barriers that require the constructionof numerous ascending and descending sections. This type of transportation mode is an alternativeto other traditional means of transport such as trains, trucks, and conveyors. The chapter coversa variety of topics related to slurry pipelines, including their advantages and disadvantages, slurryproperties, hydraulics, infrastructure, commissioning and operation, and pipeline integrity.