The use of preprints, research manuscripts shared publicly before the traditional peer-review process, is becoming more common in the life sciences. Early career researchers (ECRs) benefit from posting preprints as they are shareable, citable, and prove productivity. However, the decision to preprint a manuscript involves a discussion among all co-authors, and ECRs are often not the decision-makers. Therefore, ECRs may find themselves in situations where they are interested in posting a preprint but are unsure how to approach their co-authors or advisor about preprinting. Leveraging our own experiences as ECRs, and feedback from the research community, we have constructed a guide for ECRs who are considering preprinting - to enable them to take ownership over the process, and to raise awareness about preprinting options. We hope that this guide helps ECRs to initiate conversations about preprinting with co-authors and encourage them to preprint their future research.