Drug-Induced Liver Disorders: Introduction and Overview Neil Kaplowitz The Role of Cytochrome P450s in Drug-Induced Liver Disease Paul B. Watkins Oxidative Stress, Antioxidant Defense, and Liver Injury Hartmut Jaeschke Hepatotoxicity Due to Mitochondrial Injury Dominique Pessayre, Abdellah Mansour, Bernard Fromenty, and Alain Berson Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity Neil Kaplowitz The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis Peter L.M. Jansen and Michael Muller Immunological Mechanism in Liver Injury Petra Obermayer-Straub and Michael Peter Manns Mechanistic Role of Acyl Glucuronides Chunze Li and Leslie Z. Benet Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity Debra L. Laskin and Carol R. Gardner Roles of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis after Liver Injury Rebecca Taub, Meena Bansal, and Wei Lei Clinicopathological Patterns of Drug-Induced Liver Disease Willis C. Maddrey Histopathology of Drug-Induced Liver Disease Gary C. Kanel Mechanisms of Acetaminophen-Induced Liver Disease Sidney D. Nelson and Sam A. Bruschi Acetaminophen: Pathology and Clinical Presentation of Hepatoxicity William A. Lee and George Ostapowicz Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs Urs A. Boelsterli Nonsteroidal Anti-Inflammatory Drugs: Pathology and Clinical Presentation of Hepatotoxicity James H. Lewis Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity Of Anesthetic Agents J. Gerald Kenna Anticonvulsant Agents J. Steven Leeder and Munir Pirmohamed Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse Kia Saeian and K. Rajender Reddy Antibacterials and Antifungal Agents Jean Frederic Westphal and Jean Marie Brogard Antituberculous Agents-Induced Liver Disease Pramod Kumar Garg and Rakesh Kumar Tandon Hepatic Injury from Antiviral Agents Maurizio Bonacini, Stan Louie, and Kevin Weissman Hepatotoxicity of Cardiovascular and Antidiabetic Drugs Felix A. de la Iglesia, Jeffrey R. Haskins, and George Feuer Cancer Chemotherapy Laurie D. DeLeve Immunomodulating Agents and the Transplant Situation Mary F. Hebert, Shari L. Taylor, and Robert L. Carithers, Jr. Methotrexate Controversies Adrian Reuben Adverse Effects of Hormones and Hormone Antagonists on the Liver Muhammad Naeem and Steven Schenker Alternative Medicine, Vitamins, and Natural Hepatotoxins Georges-Philippe Pageaux and Dominique Larrey Occupational and Environmental Hepatotoxicity Keith G. Tolman Regulatory Perspectives John R. Senior Index