descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1990 English Publisher:Informa UK LimitedJournal:Autoimmunity, volume 8, pages 3-7 (issn: 0891-6934, eissn: 1607-842X,

Authors: James H. McKillop; H. Bradley; L. M. Buchanan; John A. Thomson; Rhoda Wilson; William Ewen Smith;

doi: 10.3109/08916939008998426

pmid: 2129783

The Effect of Carbimazole Therapy on Interleukin 2, Interleukin 2 Receptors and Free Radicals

- Summary
- Subjects
- Metrics

Abstract

Levels of Interleukin 2 (IL2), IL2 receptors (IL2R) and free radical scavengers were measured in 25 Graves' disease patients prior to and following an 8 week course of Carbimazole therapy in an attempt to understand the mechanism by which the drug acts on the immune system. In untreated Graves' patients IL2R levels were elevated and IL2 levels reduced. Free radical scavengers were also reduced in these patients. Following treatment IL2R levels fell and IL2 levels rose. Levels of the free radical scanvengers also rose. It is not clear whether it is the fall in IL2R levels or the rise in the level of free radical scavengers (implying a reduction in free radical activity) which is responsible for the rise in IL2.

Related Organizations

Glasgow Royal Infirmary
United Kingdom
NHS Greater Glasgow and Clyde
United Kingdom
University of Strathclyde
United Kingdom

Keywords

Male, Carbimazole, Superoxide Dismutase, Ceruloplasmin, Receptors, Interleukin-2, Free Radical Scavengers, Glutathione, Graves Disease, Humans, Interleukin-2, Female, Phytohemagglutinins, Cells, Cultured

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	15
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average