Lublin H, Kistrup K. Samtidige EKG-forandringer, leverpavirkning og vaegtstigning under behandling med klozapin.A 32-year-old man simultaneously developed electrocardiographic (ECG) changes, disturbed liver function and weight increase (18 kg) during clozapine treatment. The connection with clozapine treatment was established through reappearance of the reactions to repeated exposure. The ECG changes disappeared soon after treatment withdrawal, and the changes in the liver function normalized slowly during the subsequent months. The pathophysiology and clinical importance of the ECG changes during neuroleptic treatment are still not clear, so any ECG changes have to be evaluated individually to determine the potential clinical impact and to minimize the risk for the patient.Clozapine, ECG changes, Liver function, Weight gain