Resistance of Tumor-Derived DNA to Restriction Enzyme Digestion
Copyright policy )Resistance of Tumor-Derived DNA to Restriction Enzyme Digestion
The major finding of this work is that there are specific restriction enzyme inhibitors present in "purified" tumor DNA which cause partial digestion patterns when tumor DNA is digested by standard procedures with any of three commonly employed restriction enzymes (HindIII, KpnI, XbaI). These aberrant patterns are not seen when DNA of cell lines derived from these tumors is digested. Thus, when working with tumor DNA these restriction enzymes should be used with caution.
- New York University United States
- New York University Langone Medical Center United States
Male, Mice, Urinary Bladder Neoplasms, Animals, Humans, Mice, Nude, Coronary Disease, DNA Restriction Enzymes, DNA, Neoplasm, Cell Line, Transformed
Male, Mice, Urinary Bladder Neoplasms, Animals, Humans, Mice, Nude, Coronary Disease, DNA Restriction Enzymes, DNA, Neoplasm, Cell Line, Transformed
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