Colchicine myopathy typically presents as painless muscle weakness. This report describes a post renal-transplant patient who presented with pain in both extremities bilaterally that was refractory to narcotic analgesics. He had been on low dose daily colchicine for 7 years. Laboratory, EMG, and biopsy findings all supported the diagnosis of colchicine myopathy. Symptoms subsided after discontinuation of colchicine. Myalgia as chief complaint is an unusual presentation of colchicine myopathy.