descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1981 English Publisher:Informa UK LimitedJournal:Xenobiotica, volume 11, pages 385-390 (issn: 0049-8254, eissn: 1366-5928,

Authors: Penny Gadiel; A. R. Jones; Denise Stevenson;

doi: 10.3109/00498258109045849

pmid: 7293229

The fate of oxalic acid in the Wistar rat

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Abstract

1. An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 microgram. 2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70 mg/kg) has been studied. The rate and degree of excretion are dose-dependent. 3. The excretion of urinary oxalate by the rat has been quantified after administration of two oxalate-producing xenobiotics, alpha-chlorohydrin and 1,2-dibromo-3-chloropropane. 4. Oxalate inhibits the metabolism of glucose and lactate by isolated rat kidney tubules in vitro.

Related Organizations

University of Sydney
Australia

Keywords

Male, Oxalates, Dose-Response Relationship, Drug, Hydrocarbons, Halogenated, Antinematodal Agents, Oxalic Acid, alpha-Chlorohydrin, Rats, Inbred Strains, Rats, Propane, Glucose, Kidney Tubules, Animals, Chlorohydrins

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