Nevirapine nanosuspensions for HIV reservoir targeting
Copyright policy )Nevirapine nanosuspensions for HIV reservoir targeting
In this paper we discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed enhanced cellular uptake for nanonized nevirapine with no added cytotoxicity. Gamma scintigraphy showed that the nanosuspension prepared can be used to target spleen, thymus and lungs, which represent anatomical viral reservoirs. Thus nevirapine nanosuspensions with targeting potential have been prepared successfully.
Male, Anti-HIV Agents, Cell Survival, Macrophages, In Vitro Techniques, Kidney, Microscopy, Atomic Force, Cell Line, Mice, Isotope Labeling, Electrochemistry, HIV-1, Animals, Nanoparticles, Infusions, Parenteral, Nevirapine, Particle Size, Coloring Agents, Chelating Agents, Disease Reservoirs
Male, Anti-HIV Agents, Cell Survival, Macrophages, In Vitro Techniques, Kidney, Microscopy, Atomic Force, Cell Line, Mice, Isotope Labeling, Electrochemistry, HIV-1, Animals, Nanoparticles, Infusions, Parenteral, Nevirapine, Particle Size, Coloring Agents, Chelating Agents, Disease Reservoirs
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