The cultivation of halophytes is an alternative approach to sustain agricultural productivity under changing climate. They are densely equipped with a diverse group of metabolites that serve multiple functions, such as providing tolerance to plants against extreme conditions, being used as a food source by humans and ruminants and containing bioactive compounds of medicinal importance. However, some metabolites, when synthesized in greater concentration above their threshold level, are considered antinutrients. Widely reported antinutrients include terpenes, saponins, phytate, alkaloids, cyanides, tannins, lectins, protease inhibitors, calcium oxalate, etc. They reduce the body's ability to absorb essential nutrients from the diet and also cause serious health problems. This review focuses on antinutrients found both in wild and edible halophytes and their beneficial as well as adverse effects on human health. Efforts were made to highlight such antinutrients with scientific evidence and describe some processing methods that might help in reducing antinutrients while using halophytes as a food crop in future biosaline agriculture.