Objective — to assess changes of vitamin E level in adolescent girls with uterine hypoplasia against the background of hypomenstrual syndrome (HMS) during follow-up study.Materials and methods. We examined 40 adolescent girls, aged 14–18 years, with HMS against the background of uterine hypoplasia, particularly those with oligomenorrhea (OM) and secondary amenorrhea (SA), vitamin E level in whose blood serum we had determined before and after the 2 weeks of treatment. Patients were subjected to background therapy and ultraphonophoresis (UP) of vitamin E.Results and discussion. In the process of follow-up study we identified a correction of tocopherol level in blood serum of patients with HMS: increase in frequency of normal indices and decrease in that of low ones. Moreover, during background therapy this is observed mostly in girls with OM, while during treatment with UP of vitamin E it is evident mostly in those with SA. With background therapy positive dynamics of change in tocopherol level are more frequently registered in girls with ineffective treatment, while in case of using UP of vitamin E they are more often registered in patients with effective treatment.Conclusions. Using non-hormonal methods in treatment of adolescent girls with HMS against the background of uterine hypoplasia leads to positive dynamics of change in concentration of vitamin E, which in turn contributes to emergence of menstruations in every third girl in case of background therapy and in 61% of them in case of UP of vitamin E.