Introduction: The oral microbiota has approximately 700 symbiotic microorganisms responsible for oral health homeostasis. However, changes in oral microbiota can generate dysbiotic processes that favor the worsening of infections such as caries and periodontal disease. These oral infections, in addition to systemic involvement, can compromise the teeth integrity as well as oral health. Thus, inadequate nutrition proves to be a risk factor influencing the prevention and treatment of these oral infections. Objective: This study aims to evidence the nutritional influence on the oral microbiota modulation affecting, in the longterm, the gut microbiota, highlighting the use of probiotics and prebiotics in the treatment of oral infections by a literature review. Synthesis of data : Supplements of certain nutrients and the intake of an adequate diet in macronutrients and micronutrients directly influence nutritional status and consequently in the maintenance of oral-systemic homeostasis. In addition, due to microbial multidrug resistance, therapies using probiotics and prebiotics have been adopted as aids to the treatment of oral infections. Conclusion: Personalized Dentistry must integrate multidisciplinary knowledge of attention for health care. This in addition to knowingwhen to refer and work together with a Nutritionist.