Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ForSciencearrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ForScience
Article . 2014 . Peer-reviewed
Data sources: Crossref
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ForScience
Article
License: CC BY NC
Data sources: UnpayWall
versions View all 1 versions
addClaim

Análise matemática de um modelo para crescimento de células-tronco cancerígenas em tumores

Authors: Maria Elizabeth de Gouvea; Hoyama Maria Santos; Luís Ricardo Fernandes; Thais Oliveira Duque;

Análise matemática de um modelo para crescimento de células-tronco cancerígenas em tumores

Abstract

Apresenta-se um modelo matemático baseado na hipótese de que o crescimento de tumores tem sua origem nas células-tronco cancerígenas (CTCs). No entanto, o próprio conceito de célula-tronco cancerígena (CTC) tem sido alvo de controvérsias na literatura e uma das questões abertas à discussão se refere à proporção de CTCs em um tumor. O modelo apresentado, baseado no comportamento do sistema hematopoiético, tem uma estrutura hierárquica composta de dois compartimentos: o de células-tronco (CT) e o de células diferenciadas ou progenitoras (CPs). Admite-se que um tumor seja constituído por uma população de células que se tornaram anormais por adquirirem mutações durante o processo de mitose. Para o modelo matemático proposto, mostramos que as CTCs podem ser células anormais que residem no compartimento de células-tronco, mas também podem ser CPs que, através de mutação adquirida na mitose, se tornam capazes de se autorrenovarem. Mostramos, em concordância com resultados experimentais, que a proporção de CTCs em um tumor pode variar de acordo com a mutação que o originou. Nosso modelo sugere que os tumores mais agressivos são aqueles em que a proporção de CTCs é grande.Palavras-chave: Modelo matemático. Célula-tronco cancerígena. Tumor. Mathematical analysis of a model for the cancer stem cells growing in tumors We present a mathematical model based on the hypothesis that the growing of a tumor is driven by the cancer stem cells (CSC). However, the concept of CSC and the proportion of this subpopulation in a tumor remain as topics of considerable controversy. Our model, based on the known behavior of the hematopoietic system, has a hierarchical structure with only two compartments: one for the stem-cells (SC) and another for the differentiated or progenitor cells (PC). We admit that a tumor is constituted by a population of abnormal cells, that is, cells that, during mitosis, acquired a mutation. Our mathematical model suggests that a CSC can either be a cell residing in the stem cell compartment or a differentiated cell that, due to the mutation, became able of self-renewal. In accordance to some experimental results, our model shows that any proportion of CSC is possible in a tumor. However, the bigger this proportion is, the more aggressive is the tumor.Keywords: Mathematical model. Cancer stem cell. Tumor. 

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold
Related to Research communities
Cancer Research