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EFSA Supporting Publications
Article . 2024 . Peer-reviewed
Data sources: Crossref
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Data collection, hazard characterisation and establishment of cumulative assessment groups of pesticides for specific effects on the thyroid: 2024 update

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2024Publisher:WileyJournal:EFSA Supporting Publications, volume 21 (issn: 2397-8325, eissn: 2397-8325, Copyright policy )
Authors: Francesca Metruccio; Ilaria Castelli; Alessandra Baroni; Martina Marazzini; Teresa Mammone; Luca Tosti;

doi: 10.2903/sp.efsa.2024.en-9012

Data collection, hazard characterisation and establishment of cumulative assessment groups of pesticides for specific effects on the thyroid: 2024 update

Abstract

Abstract This report evaluates the thyroid‐related effects of various active substances and metabolites, categorizing them into Cumulative Assessment Groups (CAGs) based on indicators of hypothyroidism and C‐cell effects. 21 active substances and six metabolites were scrutinized resulting in 18 substances and three metabolites for hypothyroidism (CAG‐TCF) and two substances for C‐cell hypertrophy, hyperplasia, and neoplasia (CAG‐TCP). Detailed NOAEL and LOAEL values were derived for each substance, highlighting differences between current findings and previous assessments. The analysis reveals uncertainties due to variations in data quality and study durations. Overall, the report provides a comprehensive hazard characterization of substances affecting thyroid function, contributing to cumulative risk assessment update for effects on the thyroid.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Published in a Diamond OA journal