Abstract Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 10 compounds belonging to chemical group 21 (aromatic ketones, secondary alcohols and related esters). They are currently authorised as flavours in food. This opinion concerns eight compounds from this group. The FEEDAP Panel established the following conclusions: 4‐(4‐hydroxyphenyl)butan‐2‐one [07.055] is safe at 25 mg/kg complete feed for all target species except chickens for fattening, laying hens and cats, for which 5 mg/kg is considered safe; acetophenone [07.004] at 25 mg/kg for salmonids, veal calves and dogs, and at 5 mg/kg for the remaining target species (4.4 mg/kg for cats); vanillyl acetone [07.005] and 4‐(4‐methoxyphenyl)‐butan‐2‐one [07.029] at 5 mg/kg for all target species; 1‐phenylethan‐1‐ol [02.064], 4‐methylacetophenone [07.022], 4‐methoxyacetophenone [07.038] and 1‐phenethyl acetate [09.178] at 5 mg/kg for all species, except cats for which 1 mg/kg is considered safe. No safety concern would arise for the consumer from the use of these compounds up to the highest proposed level in feeds. Hazards for skin and eye contact and respiratory exposure are recognised for the majority of the compounds under application. Most are classified as irritating to the respiratory system. The proposed maximum use levels in feed are unlikely to have detrimental effects on the terrestrial and fresh water environments, with the exceptions of 4‐(4‐hydroxyphenyl)butan‐2‐one [07.055] and 1‐phenethyl acetate [09.178] for which the normal use levels are considered safe. For 1‐phenylethan‐1‐ol [02.064], it was not possible to reach a conclusion on the safety for the terrestrial compartment. Because all the compounds under assessment are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.