Where the physical and environmental characteristics of the coast and estuary change dramatically and complicatedly due to the multiple controlling sources as like as the tide, wave, river discharge, in order to collect the environmental data effectively and reliably, the locations of monitoring should be optimally determined with the standardized framework. The present study proposes a protocol to find the best monitoring location in a local bay based on a spatial and temporal optimizing method. With the simulation data from the accurately validated numerical model, the monitoring locations are designed with the constrained optimization method, which finds the optimal solution by constraining the objective function into the design space. The objective and constrained functions are determined from the objective analysis, which is combined with constrained optimization. Finally, those two functions are used to find the optimal solutions of the locations.