
doi: 10.2745/dds.26.457
NGF(Nerve growth factor)は, 元来, 感覚神経や交感神経の発達・増殖や機能維持に必須の因子として同定された. 近年, NGFは炎症性・炎症性疼痛などの慢性疼痛に深く関わることが明らかとなってきた. NGFの阻害薬は, 既存の治療薬が効かない多くの患者に対する新規の治療法と期待されている.本概説では, NGFが疼痛を惹起するメカニズムやその治療応用についてこれまでの研究報告をまとめる.
NGF, pain
NGF, pain
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