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Superfamily 1 helicases

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2013 United Kingdom Publisher:IMR PressJournal:Frontiers in Bioscience, volume S5, pages 206-216 (issn: 1945-0516, eissn: 1945-0524,

Authors: Gilhooly, Neville Surain; Gwynn, Emma Jane; Dillingham, Mark Simon;

doi: 10.2741/s367

pmid: 23277046

handle: 1983/33783e85-c23c-42ac-9f35-2041334d8474

Superfamily 1 helicases

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Abstract

Superfamily 1 helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along, and concomitant unwinding of, DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and, accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination and repair as well as many aspects of RNA metabolism. This review discusses our current understanding of the structure, function and mechanism of Superfamily 1 helicases.

Country

United Kingdom

Related Organizations

University of Bristol
United Kingdom
University of Bristol
United Kingdom
University of Bristol (UoB)
United Kingdom
University of Bristol, School of Biochemistry
United Kingdom

Keywords

570, 616, DNA Helicases, Humans, RNA Helicases

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