Clinical biomarkers in esophageal adenocarcinoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2010 Italy English Publisher:IMR PressJournal:Frontiers in Bioscience, volume E2, pages 489-494 (issn: 1945-0494, eissn: 1945-0508,

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Authors: BIONDI, Antonio Giuseppe; MIGLIORE, Marcello; STRANO G; VADALA S; TROPEA A; BASILE, Francesco;

doi: 10.2741/e107

pmid: 20036895

handle: 20.500.11769/6851

Clinical biomarkers in esophageal adenocarcinoma

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Abstract

This review describes genetic and molecular changes related to adenocarcinoma of the esophagus and gastroesophageal junction (GEJ) with emphasis on prognostic value and possibilities for targeted therapy in clinical setting. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma.

Country

Italy

Related Organizations

University of Catania
Italy
National Institute for Nuclear Physics
Italy

Keywords

Genetic Markers, Mucous Membrane, General Immunology and Microbiology, Esophageal Neoplasms, Adenocarcinoma, Immunohistochemistry, General Biochemistry, Genetics and Molecular Biology, Barrett Esophagus, Risk Factors, Biomarkers, Tumor, Disease Progression, Humans, Ultrasonography

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