Nuclear Structure - Skeletal Gene Expression Interrelationships
Copyright policy )Nuclear Structure - Skeletal Gene Expression Interrelationships
Using the osteocalcin gene as a paradigm for bone tissue-specific transcription, evidence is presented for functional linkage of nuclear architecture with developmental and steroid hormone-responsive control. The involvement of chromatin structure, nucleosome organization and the nuclear matrix is evaluated within the context of integrating regulatory signals that activate and/or suppress transcription of the osteocalcin gene. Mechanisms are evaluated which direct the bone and hematopoietic-specific acute myelogenous leukemia/core binding factor (AML/CBF) transcription factors to nuclear matrix-associated subnuclear domains that are competent to support expression.
- University of Massachusetts Amherst United States
- University of Massachusetts Medical School United States
- UMass Memorial Medical Center United States
- UMass Memorial Health Care United States
Cell Nucleus, 570, Osteosarcoma, Osteoblasts, Osteocalcin, NF-kappa B, 500, Core Binding Factor alpha Subunits, Gene Expression Regulation, Developmental, Bone and Bones, Chromatin, Nucleosomes, Protein Structure, Tertiary, Receptors, Glucocorticoid, Cell Line, Tumor, Nuclear Pore, Animals, Humans, Nuclear Matrix, Promoter Regions, Genetic, Signal Transduction, Transcription Factors
Cell Nucleus, 570, Osteosarcoma, Osteoblasts, Osteocalcin, NF-kappa B, 500, Core Binding Factor alpha Subunits, Gene Expression Regulation, Developmental, Bone and Bones, Chromatin, Nucleosomes, Protein Structure, Tertiary, Receptors, Glucocorticoid, Cell Line, Tumor, Nuclear Pore, Animals, Humans, Nuclear Matrix, Promoter Regions, Genetic, Signal Transduction, Transcription Factors
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