Tight junctions in cancer metastasis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2011 English Publisher:IMR PressJournal:Frontiers in Bioscience, volume 16, page 898 (issn: 1093-9946, eissn: 1093-4715,

Copyright policy )

Authors: Tracey A, Martin; Malcolm D, Mason; Wen G, Jiang;

doi: 10.2741/3726

pmid: 21196209

Tight junctions in cancer metastasis

- Summary
- Subjects
- Metrics

Abstract

Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.

Related Organizations

Cardiff University
United Kingdom

Keywords

Male, Coxsackie and Adenovirus Receptor-Like Membrane Protein, Lung Neoplasms, Esophageal Neoplasms, Brain Neoplasms, Genital Neoplasms, Female, Liver Neoplasms, Nectins, Immunoglobulins, Membrane Proteins, Breast Neoplasms, Epithelium, Kidney Neoplasms, Claudins, Animals, Humans, Female, Colorectal Neoplasms, Cell Adhesion Molecules, Melanoma

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	97
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%