Replication protein A: directing traffic at the intersection of replication and repair
Copyright policy )Replication protein A: directing traffic at the intersection of replication and repair
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.
- University System of Ohio United States
- University of Nebraska Medical Center United States
- University of Toledo United States
DNA Replication, Recombination, Genetic, DNA Repair, Replication Protein A, Animals, DNA, Single-Stranded, Humans, DNA Damage, Protein Binding
DNA Replication, Recombination, Genetic, DNA Repair, Replication Protein A, Animals, DNA, Single-Stranded, Humans, DNA Damage, Protein Binding
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