Bone phenotypes of P2 receptor knockout mice
Copyright policy )Bone phenotypes of P2 receptor knockout mice
The action of extracellular nucleotides is mediated by ionotropic P2X receptors and G-protein coupled P2Y receptors. The human genome contains 7 P2X and 8 P2Y receptor genes. Knockout mice strains are available for most of them. As their phenotypic analysis is progressing, bone abnormalities have been observed in an impressive number of these mice: distinct abnormalities in P2X7-/- mice, depending on the gene targeting construct and the genetic background, decreased bone mass in P2Y1-/- mice, increased bone mass in P2Y2-/- mice, decreased bone resorption in P2Y6-/- mice, decreased bone formation and bone resorption in P2Y13-/- mice. These findings demonstrate the unexpected importance of extracellular nucleotide signalling in the regulation of bone metabolism via multiple P2 receptors and distinct mechanisms involving both osteoblasts and osteoclasts.
- University College London United Kingdom
- Université Libre de Bruxelles Belgium
P2 receptors, Purinergic P2 -- genetics, Knockout, Review, Bone and Bones, Bone Density -- genetics, Signal Transduction -- genetics, Mice, Bone Density, Nucleotides -- metabolism, Receptors, Animals, Bone Resorption, Bone, Bone Resorption -- genetics, Mice, Knockout, Nucleotides, Receptors, Purinergic P2, Extracellular Space -- metabolism, Sciences biomédicales, Bone and Bones -- abnormalities -- metabolism, Phenotype, Gene Targeting, Extracellular Space, Signal Transduction
P2 receptors, Purinergic P2 -- genetics, Knockout, Review, Bone and Bones, Bone Density -- genetics, Signal Transduction -- genetics, Mice, Bone Density, Nucleotides -- metabolism, Receptors, Animals, Bone Resorption, Bone, Bone Resorption -- genetics, Mice, Knockout, Nucleotides, Receptors, Purinergic P2, Extracellular Space -- metabolism, Sciences biomédicales, Bone and Bones -- abnormalities -- metabolism, Phenotype, Gene Targeting, Extracellular Space, Signal Transduction
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