Mechanisms of X-chromosome inactivation
Copyright policy )Mechanisms of X-chromosome inactivation
Mammalian X-chromosome inactivation is an impressive example of epigenetic gene regulation, whereby the majority of genes on the approximately 160 Mb X chromosome are silenced in a strictly cis-limited fashion. In this review we will discuss the important players involved in the silencing process. The process is initiated by transcription and cis-localization of the non-coding XIST RNA, which then recruits many of the epigenetic features generally associated with heterochromatin, including histone modifications, histone variants and DNA methylation.
Chromosomes, Human, X, RNA, Untranslated, Models, Genetic, Transcription, Genetic, DNA Methylation, Models, Biological, Epigenesis, Genetic, Histones, Mice, X Chromosome Inactivation, Dosage Compensation, Genetic, Heterochromatin, Animals, Humans, Gene Silencing, Transcription Factors
Chromosomes, Human, X, RNA, Untranslated, Models, Genetic, Transcription, Genetic, DNA Methylation, Models, Biological, Epigenesis, Genetic, Histones, Mice, X Chromosome Inactivation, Dosage Compensation, Genetic, Heterochromatin, Animals, Humans, Gene Silencing, Transcription Factors
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