Transglutaminase and diseases of the central nervous system

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2005 France English Publisher:IMR PressJournal:Frontiers in Bioscience, volume 10, page 3,078 (issn: 1093-9946, eissn: 1093-4715,

Copyright policy )

Authors: Hoffner, Guylaine; Djian, Philippe;

doi: 10.2741/1764

pmid: 15970562

Transglutaminase and diseases of the central nervous system

- Summary
- Subjects
- Metrics

Abstract

Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.

Country

France

Related Organizations

École Polytechnique
France
Université Paris Cité
France
Centre national de la recherche scientifique
France

Keywords

MESH: Humans, Transglutaminases, MESH: Peptides, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Neurodegenerative Diseases, Parkinson Disease, MESH: Huntington Disease, MESH: Neurodegenerative Diseases, Huntington Disease, MESH: Transglutaminases, Alzheimer Disease, Humans, Peptides, Molecular Biology, MESH: Alzheimer Disease, MESH: Parkinson Disease

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	26
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%