The MISA Case Competition is an undergraduate research conference organized by the Microbiology and Immunology Student Association (MISA) at Western University. It promotes innovation, collaboration, and scientific thinking among students interested in the life sciences. Now in its third year, the 2025 competition challenged undergraduate teams to develop a novel approach using synthetic biology in personalized medicine to address a health issue or disease of their choice. Teams could focus on prevention, diagnosis, or treatment, and were encouraged to enhance existing strategies by introducing innovative elements supported by current scientific literature. The top six teams presented their proposals to a panel of faculty judges from the Department of Microbiology and Immunology at Western University. The top three teams were awarded based on scientific merit, creativity, and feasibility. We hope our competition inspires the next generation of researchers to push the boundaries of science in meaningful ways. To learn more about our initiatives, visit: https://misawestern.wixsite.com/website/resources-and-projects