Objective The objective of the study was to perform the drug utilization evaluation of analgesics in the Department of General Surgery at a teaching hospital by using Anatomical and Therapeutic classification ATC code and Defined daily dose DDD100 bed days. Methods A prospective observational study was conducted in the Department of General Surgery at a teaching hospital for a period of three months. Descriptive statistics were used in which quantitative variables were presented in proportions and percentages. Consumption of analgesics in the department was measured by using the technical unit of measurement Defined Daily Dose DDD and DDD100 bed-days.Results A total of 606 subjects were included in the study. The majority of patients in the Department of General Surgery were males 360 59.4 and the female subjects were 246 40.6. Paracetamol 1g IV was observed to be the most used analgesic in this department with the units consumed being 4811 48.63. Aceclofenac 100 mg oral drug was the least used analgesic with units consumed at 29 0.29. The DDD100 bed-days for each analgesic with ATC code was calculated and analysed.Conclusion Drug utilization evaluation of analgesics in the Surgery department of the hospital based on DDD and the DDD100 bed-days measurement showed that parenteral forms of analgesics like Paracetamol Tramadol and Diclofenac were consumed more than the oral dosage forms of these drugs. The study also revealed that consumption of drugs like Tramadol and Pregabalin in the oral dosage forms was low in the hospital included in the study which shows rationality in the use of controlled drugs