Background The choice of an appropriate restorative material in pediatric dentistry is a determining factor for longevity of treated tooth. Given the unique challenges in pediatric patients the ideal material should demonstrate least possible microleakage while possessing sufficient compressive strength to withstand masticatory forces.Aim This study aimed to examine and contrast the microleakage and compressive strength of Cention N and Zirconomer both of which are widely used in pediatric dentistry.Method Fifty-two extracted human premolars were divided equally between the Cention N and Zirconomer groups for microleakage testing. Premolars were subjected to preparation of Class V cavities and then restored with either Cention N or Zirconomer based on the allocated group. Distilled water was used for premolar storage for 24 hours followed by thermocycling at 5-55degC for 250 cycles and then immersed in dye bath containing 2 methylene blue for a duration of 24 hours. The specimens were buccolingually sectioned examined under a stereomicroscope for dye penetration and scored. To evaluate compressive strength metallic moulds measuring 5 mm X 6 mm were used. Cention N and Zirconomer were prepared as per the manufacturers guidelines and placed into their respective moulds. After being stored in distilled water for 24 hours the specimens were tested for compressive strength using a universal testing device set to a crosshead speed of 1 mmmin. The strength was calculated using the formula CS Load pirsup2.Results A statistically significant difference was observed between Cention N and Zirconomer with respect to both microleakage and compressive strength Plt0.01. Cention N demonstrated lower microleakage and higher compressive strength compared to Zirconomer.Conclusion The study found that Cention N demonstrated superior performance in both microleakage resistance and compressive strength compared to Zirconomer.