The condition with a prevalence of more than 10 million cases per year in India hypertriglyceridemia poses as an independent risk factor for cardiovascular diseases as well as stroke. Medoroga is a condition where there is abnormality in the metabolism and deposition of Medo Dhatu. Diagnosing it as a Santarpanajanya Vikara Apatarpana in the form of Shodhana is needed to manage and prevent its complications. This report presents a case of a 49 year old obese female a known hypertensive since eight years who was found to have severe hypertriglyceridemia gt500 mgdL on routine blood screening. She was subjected to Virechana Karma attaining Pravara Shuddhi. Patientrsquos serum triglyceride levels showed remarkable reduction after the Shodhana therapy alone.nbsp