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Formulation and characterization of sevelamer carbonate immediate release tablets

Authors: {\\"name\\":\\"Vadamala Prudhvi Raj\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affiliat; {\\"name\\":\\"L G Chaithra\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affiliati; {\\"name\\":\\"P Mounika\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affiliation\\"; {\\"name\\":\\"M Naga Gouthami\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affili; {\\"name\\":\\"C Swapna\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affiliation\\":; {\\"name\\":\\"D Vandana\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affiliation\\"; {\\"name\\":\\"Y Jagadeesh\\",\\"email\\":\\"prudhvirajpharma9@gmail.com\\",\\"affiliatio; +1 Authors

Formulation and characterization of sevelamer carbonate immediate release tablets

Abstract

The present study aimed to formulate and evaluate a pharmaceutical study on formulating and characterising immediate - release tablets of Sevelamer carbonate, a non - absorbable phosphate binder used to treat hyperphosphatemia in chronic kidney disease patient s.Six formulations (F1 - F6) were developed using wet granulation with varying super disintegrants like cross - povidone and croscarmellose sodium, alongside excipients such as microcrystalline cellulose, magnesium stearate, and talc, followed by comprehensive pre - formulation, compression, and quality control evaluations, including FTIR compatibility, flow properties, weight variation, hardness, friability, disintegration, dissolution, and stability testing. Key findings highlight good powder flow (e.g., bulk d ensity 0.714 g/ml, Hausner's ratio 1.16), tablet quality within USP limits (friability 0.79%, disintegration ~2.18 min), and optimal drug release up to 82.56% at 90 minutes for F3, confirming suitability for rapid phosphate binding without drug - excipient i nteractions or stability issues over tested periods.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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